Endocrine Abstracts

Introduction: The pathogenesis of pituitary adenomas is incompletely understood. It was recently demonstrated that mutations in AIP, a novel tumor suppressor gene, are causing the familial isolated pituitary adenoma syndrome. Although initial data suggested that AIP mutations are rare in non-familial cases, a recent study demonstrated an increased prevalence in young sporadic macroadenoma patients.Aim: To perform a systematic screening of AIP mutations i...

Introduction: The concentrations of pituitary hormones in the cerebrospinal fluid (CSF) are much lower that their serum counterpart.Aim: To study the CSF access for pituitary glycoprotein hormones (GPH) in patients with pituitary adenomas (PA).Patients and methods: In 221 cases submitted to transsphenoidal surgery for PA (85 acromegaly – ACM, 92 nonfunctioning pituitary adenomas – NFA, 44 prolactinomas – PRM) the sur...

Introduction: Monoclonality of pituitary adenomas is an established fact. Still, there are exceptions and polyclonality may correlate with aggressive tumor behavior. In order to test association of clonality with pituitary adenoma characteristics in a series from Romania, we implemented a protocol for X-chromosome inactivation analysis at the androgen receptor (AR) locus (HUMARA) and validated it in a number of tumor samples.Objective: To establish and v...